Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BYF1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ACE2 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | knockdown of TRIM28 induces enzyme (ACE2) expression. TRIM28 knockdown enhances interferon-gamma (IFN-gamma)-induced ACE2 expression through a mechanism involving upregulating IFN-gamma receptor 2 (IFNGR2) in both A549 and PAEpiCs. The upregulated ACE2 induced by TRIM28 knockdown and co-culture of NK cells is partially reversed by dexamethasone in A-549 cells. TRIM28 is a novel regulator of ACE2 expression and SARS-CoV-2 cell entry | up |
General Information | Comment | Organism |
---|---|---|
physiological function | severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease, it binds to angiotensin-converting enzyme 2 (ACE2) to enter into human cells. The expression level of ACE2 potentially determines the susceptibility and severity of COVID-19 | Homo sapiens |